Fluoxymesterone (Halotestin) – tableted anabolic steroid with a pronounced androgenic and anabolic effect relatively weak. It is mainly used to improve athletic performance, muscle density and aggression, without increasing the total body weight. The mean specific activity of Halotestin is used mainly strength athletes who do not want to increase the weight class, as well as in boxing and other combat sports, directly in front of the competition. Fluoxymesterone is highly toxic to the liver. The exact mechanism of action has not yet been studied, it is assumed non-receptor effect on the muscles.
The steroid profile
· Anabolic activity – 1900% of testosterone
· Androgenic activity – 850% of the testosterone (very high)
· Aromatization (conversion to estrogen) – No
· The suppression of the hypothalamic-pituitary-testes – expressed
· Toxicity to the liver – very high
· A method for receiving – orally (tablets)
· Duration – 6-9 hours
· Detection time – 2 months
Pharmacological Properties and Effects
Initially used as fluoxymesterone agent with pronounced androgenic properties used in the treatment of male hypogonadism and delayed puberty in males for the treatment of breast cancer in women. Nowadays medicine refuse to use it. Halotestin is about five times more powerful than methyltestosterone.
Halotestin (Fluoxymesterone) is similar in structure to methyltestosterone. It was developed by modifications of testosterone in three positions: 17-alpha-methyl group of 11-beta-hydroxy and 9-flyuorogruppa.
The first chemical modification allows to extend the half-life of the drug when administered orally and neutralize destructive first-pass effect through the liver, while maintaining the maximum concentration of active substance in the blood.
The second modification is aimed at preventing the enzymatic conversion of the molecule by attaching it to the aromatic ring, in other words, the drug is not converted into estrogen. It is supposed to block the ability of estrogen and prolactin receptors, which excludes the risk of gynecomastia, edema and fat deposition on the female type.
The latter group determines the name of the drug (fluoxymesterone) and is aimed at improving the androgenic activity of the drug (5a facilitates a reduction in the position, which leads to the formation of digitrotestosterona). It is the active form of the drug circulating in the blood normally in small quantities, greatly exceeds the activity of testosterone and can bind tightly to androgen receptors in cells of organs and muscle tissue.
It was also noted that the drug improves aerobic performance of athletes in track and field. It is associated with the ability to stimulate erythropoiesis, hemoglobin synthesis. At the same time increasing the number of red blood cells is able to more efficiently transport oxygen to the cells.
Fluoxymesterone may be used to burn fat, as it was shown that the drug enhances oksislenie fatty acids in the fast-twitch muscle fibers. Although for this purpose there is also a safe and effective anabolic agent, particularly Winstrol, testosterone, oxandrolone.
With the increased speed of the formation of DHT from testosterone is associated hypertrophy and hyperplasia of the prostate, the development of BPH and may increase the likelihood of developing cancer. Relatively easy ability of the drug to move into dihydrotestosterone may further have adverse health effects in terms of its long-term use. Fluoxymesterone is judged as a drug that exceeds 19 in the testosterone anabolic capacity, 8. 5 times and androgenic properties. Information about the activity of the drug was obtained experimentally.
Halotestin is toxic to the liver. Athletes use the drug frequently report an increase in morbidity and organ. Studies have shown that the drug will certainly lead to increased levels of liver enzymes, indicating that the steady process of increasing degradation of liver cells under the influence of fluoxymesterone. This fact is confirmed by literary sources.
The optimal dose of Halotestin is 10mg / day is recommended not to exceed the dose of 20 mg / day. In addition, long-term use Halotestin (6 weeks) may harm sexual function. Based on the ratio of benefits and harms, holding Halotestin most appropriate course just before the competition, in order to obtain two basic effects to enhance the physical strength and aggression.
Fluoxymesterone is virtually muscle growth. Drug combination with other anabolic agents also have special advantages.
Halotestin is an oral steroid which was introduced on the market by Upjohn Company in 1957. Fluoxymesterone substance is precursor of methyltestosterone. Through its changes in the chemical structure, was made much more androgenic than testosterone. The anabolic component is only slightly pronounced. Based on its characteristics Halotestin is used mainly when the athlete is more interested in a strength build up rather than in a muscle gain. Powerlifters and weightlifters who must stay within a certain weight class often use this drug because they are primarily interested in a strength gain without adding body weight.
In bodybuilding Halotestin is almost exclusively taken during preparation for a competition. Since its substance is strongly androgenic while at the same time aromatizing very poorly, this substance helps the athlete obtain an elevated androgen level while keeping the estrogen concentration low.