Insulin – peptide hormone, produced in the beta cells of the islets of Langerhans of the pancreas. It has a multifaceted effect on the exchange of almost all tissues. The main effect is to reduce the insulin concentration in blood glucose. In bodybuilding, insulin is used due to its pronounced anabolic effect. An alternative are oral hypoglycemic agents such as Diabeton.
Insulin increases the permeability of plasma membrane glucose activates key enzymes of glycolysis, stimulates formation in the liver and muscle glycogen from glucose, increases the synthesis of fats and proteins. In addition, insulin suppresses the activity of enzymes that break down glycogen and fat. That is, in addition to the anabolic action of insulin also possesses anti-catabolic effect.
The worst effects of insulin dependent glucose transport in the two types of tissues: muscle tissue and fat tissue – is the so-called insulin-dependent tissues.
Metabolic effects of insulin
· increased glucose uptake by cells and other substances;
· activation of key enzymes of glycolysis;
· increase the intensity of glycogen synthesis – insulin forces the storage of glucose by the liver cells and muscle by polymerizing it into glycogen;
· decrease gluconeogenesis intensity – decreases education at liver glucose of different matternon-carbohydrate nature (proteins and fats).
Anabolic action of insulin
· cells enhances the absorption of amino acids (especially leucine and valine);
· enhances transport potassium ions in the cell, as well as magnesium, and phosphate;
· amplifies DNA replication and protein biosynthesis;
· It promotes the synthesis of fatty acids and subsequent esterification – in adipose tissue and liver insulin promotes the conversion of glucose into triglycerides; with a lack of insulin the opposite happens – the mobilization of fats.
Anti-catabolic action of insulin
· It inhibits the hydrolysis of proteins – reduces the degradation of proteins;
· reduces lipolysis – reduces the intake of fatty acids in the blood.
Details: mechanisms of action
The risk of insulin – a lethal dose
Perhaps the main factor in the poor reputation of insulin – the risk of hypoglycemia. On any forum posts can be found cautionary character, as if even a slight excess dose of insulin can be fatal.However, scientific and practical data tell a different story: Dr. G Kernbach-Wighton and colleagues have determined that the minimum lethal dose of insulin – 100 units, that is, the full insulin syringe Many people are still alive even after doses of 3000 IU.! Even in the event of a serious overdose of insulin is time to call an ambulance in clear consciousness. Prior to the development of coma takes several hours, so even fatal dose of insulin do not cause death, if the start timely receipt of glucose in the blood.
Which insulin is used in bodybuilding
In bodybuilding, you should use insulin and short-acting:
Short insulin takes effect when administered subcutaneously within 30 minutes (so administered 30-40 minutes before a meal), the peak of the action occurs in 2 hours, disappears from the body within 5-6 hours.
This description was taken directly from Brian Raupp’s Anabolix Research page since this drug is so dangerous and his description is by far the most comprehensive that I have found on the internet.
Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscles.
In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia.