In order to increase the body muscle mass began to insufficient availability of the building materials in the form of dietary supplements or special amino acids (muscle tissue is composed mainly of protein, if not taking into account the water). Should be given to the team that, unlike the team raise a hand, does not come from the cerebral cortex, and through release into the blood of anabolic hormones, chief among which is the male sex hormone testosterone.
To meet the requirements of sports competitions bodybuilding own testosterone is not enough to achieve the goal, and the athletes have to enter it from the outside in addition, in the form of pills or injections. But there is a problem, which is called aromatization. Based on the cytochrome P450 enzyme aromatase converts testosterone molecule, splitting off the methyl in tenth position and aromatiziruya tsiklopentanpergidrofenantrenovoe core. This produces female sex hormones (estrogens) – estrone and estradiol. They cause the growth of mammary glands (gynecomastia), water retention, obesity is on the female type and a dangerous increase in blood pressure.
It can be controlled in three ways With these side effects. First – is the use of testosterone synthetic substitutes that are unaffected by aromatase. II – receiving drugs that inhibit the action of this enzyme. Third – is the use of pharmaceutical agents that block receptors of estrogen in the body tissues, thus depriving them of the ability to have a physiological effect and cause side effects listed. Among the latter group relates clomiphene formulations marketed in the form of citric acid ester – citrate.
Clomiphene is a selective estrogen receptor blocker that blocks them in the pituitary. This destroys the negative feedback mechanism and thereby stimulates the pituitary luteinizing hormone, which increases the production of testosterone by the testes. In addition to clomiphene, tamoxifen has such an effect, but it increases the number of progesterone receptors, which makes it impossible to appointment with progestin anabolics, such as nandrolone and the like. Therefore, when using these anabolic Clomiphene is the drug of choice.
Clomiphene Citrate is typically prescribed for women to aid in ovulation. In men, the application of Clomid causes an elevation of follicle stimulating hormone and luteinizing hormone. As a result, natural testosterone production is also increased.
This effect is obviously beneficial to the athlete, especially at the conclusion of a steroid cycle when endogenous testosterone levels are subnormal. When an athlete discontinues the use of steroids, his testosterone levels will most likely be suppressed. If endogenous testosterone levels are not brought to normal, a dramatic loss in size and strength may occur. Clomid plays a crucial role in preventing this crash in athletic performance.
Bodybuilders find that a daily intake of 50-100 mg of clomiphene citrate over a two week period will bring endogenous testosterone production back to an acceptable level. Clomid will gradually raise testosterone levels over its period of intake. Since an immediate boost in testosterone is often desirable, athlete will commonly use HCG (human choronic gonadotropin) for a couple of weeks, and the continue treatment with Clomid.
Clomid is also effective as an anti-estrogen. Most athletes will suffer from an elevated estrogen level at the conclusion of a cycle. A high estrogen level combined with a low testosterone level puts an athlete in serious risk of developing gynocomastia. With the intake of Clomid, the athlete gets the dual effect of blocking out some of the effects of estrogen, while also increasing endogenous testosterone production.