Description
What is Tamoxifen Citrate?
Tamoxifen Citrate is a prescription drug that is used to treat breast cancer in both men and women. It can also be used as a preventive measure for women more likely to develop breast cancer due to age, genetics, or other high risk factors.
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
Some breast cancer cells can require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. As a result, breast cancer cell growth is blocked.
Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name “tamoxifen.”
Estrogens effects on running anabolic steroids:
While running aromatising compounds, such as testosterone, aromatase in the male body will convert it to form estradiol. Too much estradiol (estrogen) in the male body can lead to several problems. The biggest problem being development of female breast tissue (gynocomastia) in men. Warning signs of this occurrence are usually associated with small lumps, swelling, puffiness and/or sensitivity in the nipple area. Without controlling this issue, things can worsen, often leading to surgery as the only way to reverse this condition. High estrogen also contributes to things like water retention and bloat leading to loss in definition and smoothing out your physical condition. Higher estrogen levels also contribute to fat gain. This is a big factor in why women typically have a higher bodyfat percentage than men.
The benefits of Tamoxifen Citrate during an anabolic steroid cycle:
It is important to know that Tamoxifen Citrate is a selective estrogen receptor modulator (SERM) and NOT an aromatose inhibitor (AI). Tamoxifen Citrate does not lower your estrogen level, but works to keep estrogen from binding to receptors in the body.
With that said, many bodybuilders will use Nolvadex as a part of their steroid cycles.
1) Taking Tamoxifen Citrate during cycle will not lower estrogen, but will keep estrogen from binding to receptors allowing one to run it in conjunction with multiple aromatising compounds without any issue. Since estrogen is necessary to build muscle, Tamoxifen Citrate can be used on cycle to maximize gains without lowering estrogen and hindering muscle gain.
2) Tamoxifen Citrate can contribute to fat burning. The effects are especially apparent with those that have very low body fat, as Tamoxifen Citrate can significantly increase hardness and lower water retention on cycle, leading to a much more dry and shredded physique.
3) Health-It’s widely known that steroid cycles can significantly put strain on your health and adversely affect your blood lipids. Estrogen is essential for a properly functioning immune system and lipid profile. Your immune system and lipid profile (both HDL and LDL) will both benefit from the administration of Tamoxifen Citrate on cycle.
4) Some bodybuilders take human chorionic gonadotropin (HCG) at the end of a steroid cycle to jump start recovery. HCG, has a structure similar to that of luteinizing hormone (LH), a pituitary gland hormone that controls testosterone synthesis in the Leydig cells of the testes. The problem is, HCG stimulates estrogen synthesis as well as testosterone. So, bodybuilders often combine HCG with Tamoxifen Citrate to prevent those estrogen side effects.
5) Gyno symptoms on cycle- Tamoxifen Citrate exerts its effects faster than an aromatase inhibitor. So, when bodybuilders experience the symptoms of gynecomastia while they are on steroid cycle, they can rely on Tamoxifen Citrate to immediately counter the problem. However, a drawback of this drug is that it exhibits only short-term effects, which means that once Tamoxifen Citrate intake is discontinued, the same problems can possibly rebound sooner than later. To prevent this rebound, Tamoxifen Citrate is generally use in conjunction with aromatase inhibitor. Tamoxifen Citrate can deal with the problem right away while an aromatase inhibitor like Arimidex can work for the long-term results as it reduces the production of estrogen.
Tamoxifen Citrate benefits for post cycle therapy (PCT):
Tamoxifen Citrate can also have a VERY profound effect on recovery of the hypothalamus pituitary testicular axis (HPTA) post-cycle of running anabolic steroids. Significant increases in Luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone are experienced with administration of Tamoxifen Citrate in PCT. some research suggests that just 20mg of Tamoxifen Citrate taken each day can raise testosterone by 150%. For reference and comparison, it would take roughly 150mg of Clomid each day to achieve the same level of result.
Tamoxifen Citrate is also safer to use long term versus some of the other alternative ancillaries commonly used post cycle. Tamoxifen Citrate has a much lower toxicity, and is just simply better suited for long term use without further having a negative impact on overall health, and even provides some nice health benefits.
Tamoxifen is antiestrogen, produced for the reason of breast cancer in women because of high estrogenic amounts in there adipose tissues. For male athletes it was used for the primarily reason to stop the effect of conversion into estrogen causing gynecomastia. The structure of estrogen is very similar to testosterone, since it can aromatize many anabolic steroids is why the buildup of estrogens can be very serious concern. Estrogen can do two things negatively in males one is the extra build of fat, secondly being the extra water retention buildup in the body.Also it can increase production of FSH (follicle stimulating hormone) and LH (leutinizing hormone) in the male body. Activating the estrogen receptor can have a positive effect on HDL (good) cholesterol values.
