Indications for use of the drug Andriol:
Men: replacement therapy for primary and secondary hypogonadism (delayed puberty, hypopituitarism, syndrome, post-castration syndrome, oligospermia); male menopause, impotence (impotentia generandi virilis), male infertility (in violation of spermatogenesis); androgen deficiency, osteoporosis due to lack of androgens. 
In women, breast cancer, dysfunctional bleeding Hyperestrogenism, uterine fibroids, endometriosis, disorders of menopause in women (with estrogen), premenstrual syndrome, breast cancer (metastatic later), osteoporosis. Read more
The active substance group:
Testosterone (Testosterone), Androgen
Dosage Form:
capsule, solution for intramuscular injection of [oil], solution for intramuscular injection of [oil-olive oil], solution for intramuscular injection of [oil, peach oil]
Contraindications:
Hypersensitivity, prostate cancer and / or breast cancer, gynecomastia, nephrosis or the nephrotic phase of nephritis, prostatic hypertrophy with urinary retention, hepatic / renal failure, hypercalcemia, edema, heart failure, diabetes mellitus, myocardial infarction, commonly atherosclerosis, pregnancy, lactation. Asthenic constitution, elderly men; adolescence boys (before puberty).
Dosage and administration:
V / m, n / a. Eunuchoidism men with congenital hypoplasia gonads, they are removed surgically or by trauma and acromegaly – 25 mg daily, or 50 mg every 1-2 days, or 100-200 mg (1-2 ml 10 % solution) 1 every 15 days. The period of treatment depends on the effectiveness of therapy and the nature of the disease. After improving clinical use supporting doses – 5.10 mg daily or every other day, or moving to a reception inside methyltestosterone.
Impotence amid functional gonadal failure, fatigue and nervous exhaustion, as well as male climacteric syndrome – 10 mg daily or 25 mg 2-3 times a week for 1-2 months.
In prostatic hypertrophy in the initial stage of 10 mg administered every other day for 1-2 months.
Women older than 45 years with dysfunctional uterine bleeding – 10-25 mg a day for 20-30 days. You must first eliminate malignant tumors of the uterus.
In vascular and neurological disorders of climacteric origin women and contraindications to the use of estrogen – 10 mg a day or 100 mg 1 time per week for 2-3 weeks.
In malignant tumors of the breast or ovarian cancer – 50 mg daily or 100 mg for a few months and then, depending on the results of the treatment dose and reduce long-designate maintaining dose (100-200 mg every 1-2 weeks).
Pharmachologic effect:
Androgenic means also has anabolic effects. The target cells (skin, prostate, seminal vesicles, epididymis) recovering the 5-alpha-reductase to 5a-dihydrotestosterone, which specifically interacts with the receptor on the cell surface and into the nucleus. In some tissues (including the hypothalamus) is converted to estradiol.
In men, it stimulates the development and activity of the gonads, prostate, seminal vesicles, the formation of secondary male characteristics (growth, deep voice, growth of beard and mustache), increases libido and potency; indirectly, through the central nervous system, affects sexual behavior. More info
Reduces fat accumulation and excretion of minerals. Inhibits the production and release of pituitary LH and FSH.
It has anabolic effects: involved in skeletal growth, increases the mass of skeletal muscles; causes a delay of nitrogen, phosphorus, K +, sulfur needed for protein synthesis.
Side effects:
Acne, seborrhea, edema, allergic reactions, increased libido, frequent erections, decreased volume of ejaculate; hypercalcemia; disruption of spermatogenesis and sperm maturation; priapism, precocious puberty boys, an increase in penis size, premature closure of the epiphyseal bone; delay Na + and water, dizziness, nausea; pain, itching, redness at the injection site; bleeding from the gastrointestinal tract, metrorrhagia, thrombophlebitis, cholestatic jaundice, increased activity of “liver” transaminases.
With prolonged use in women – virility syndrome (deepening of voice, excessive hair growth on the face and body), atrophy of the breasts, amenoreya.Peredozirovka. Symptoms: priapism.
Treatment: cessation of therapy until symptoms disappear, followed by the appointment of smaller doses.
Special instructions:
Patients with hypertension, migraine, epilepsy treatment is needed during regular medical supervision.
Interaction:
While the use of enzyme inducers of microsomal oxidation (barbiturates, rifampicin, and others.) May decrease the effectiveness of testosterone.